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This category contains websites related to Overseas research group leaders.
Overseas research group leaders
Skip [1]Wei Li
李蔚 博士：美国贝勒医学院助教授
李蔚博士的研究方向是基因组学和表观遗传组学。他在Nature, Science, Cell, Nature Genetics, PNAS, Genome Research等刊物发表论文40余篇。李蔚博士2008年获得Duncan Scholar学者奖，2009 年获得美国国防部前列腺癌研究计划新人奖。
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Dong Xu
The research focus of Digital Biology Laboratory (DBL) is Bioinformatics and Computational Biology. We are interested in various topics including protein structure prediction, high-throughput biological data analyses, primer and probe design, protein phosphorylation analysis, in silico studies of plants, cancers, viruses, and many more.
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X. Shirley Liu
刘小乐 博士：美国哈佛大学副教授
刘小乐博士工作侧重于基因调控机制的生物信息和计算生物学研究。她的科研组通过整合全基因组 ChIP-chip/Seq, 核小体定位, 组蛋白修饰, 基因表达谱, 基因组序列等数据, 构建转录与表观遗传调控的计算和统计模型。她已发表了70篇文章, 其中19篇是Nature/Cell 系列，担任19家期刊和3个国际会议的审稿人, 并且先后担任 Genomics, Annals of Applied Statistics, Biostatistics, 和 BMC Bioinformatics 的编委。刘小乐博士2002 年成为高等教育年鉴的封面人物, 获得了"Bioinformatics Whiz"和"rising star"的美誉, 2005 年获得 Claudia Adams Barr 创新基础癌症研究奖, 2006 年获得国防部前列腺癌研究计划新人奖, 2008 年获得 Sloan 基金会研究奖金。
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Cheng Li
李程 博士：美国哈佛大学副教授
李程博士的研究方向是生物信息学、计算基因组学以及在癌症和神经科学领域的应用。他开发的dChip软件和相关数据分析方法被广泛应用于基因表达和SNP 生物芯片的数据分析和展示，主要文章被引用1600次。李程博士在Nature、Nature Genetics、Blood、PNAS、BMC Genomics等刊物发表论文60篇。
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Wei Chen
The recent introduction of massively parallel sequencing technology has revolutionized genomic research. These so-called next generation sequencing platforms, such as Roche/454, Illumina/solexa and ABI/Solid system can sequence DNA orders of magnitude faster and at much lower cost than conventional Sanger method. With their incredible sequencing capacity, in additional to genomic DNA sequencing, a variety of functional genomic assays based on this new generation of sequencers have been developed and implemented in our lab, ranging from targeted mutation screening by combining next-gen sequencing technology with sequence capture methods, high throughput characterization of chromosome translocation breakpoints, ChIP-seq, RNA-seq and small RNA sequencing.
MiRNAs are small non-coding RNAs that control the expression of target genes at the posttranscriptional level. Recently, more and more miRNAs have been implicated in a variety of biological processes. Whereas many attention has been focus on finding the target genes regulated by miRNAs, little is known about the system which regulates miRNA expression. Together with our collaborators, we are establishing methods to study both transcriptional and posttranscriptional regulation of miRNA genes.
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Yang Zhang's Research Group
* Protein structure prediction
* Ligand-protein docking
* Protein-protein interactions
* G protein-coupled receptor modeling
* New drug design
Determining structure and function of protein molecules is a cornerstone of many aspects of modern biology and medicine. The main focus of our lab is to develop bioinformatics algorithms to predict 3-dimensional structures of protein molecules from amino acid sequences and then deduce the biological functions based on the sequence-to-structure-to-function paradigm. We are also working on the modeling of ligand-protein and protein-protein interactions. We are especially interested in the structures of G protein-coupled receptors (GPCR) and the interactions with the associated ligands with the purpose of developing new drugs to regulate these interactions.
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| Number of Accepted Links: | 1411 |
| Links Pending Approval: | 545 |
| Categories Pending Approval: | 375 |
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